Hit and lead profiling
identification and optimization of drug-like molecules
Our rough guess is there are 125,750 words in this book.
At a pace averaging 250 words per minute, this book will take 8 hours and 23 minutes to read. With a half hour per day, this will take 17 days to read.
How long will it take you?
This book will take an estimated to read at a reading speed averaging words per minute. With 30 minutes per day, this will take to read.
Enter your reading speedYou can take one of our WPM reading speed tests to find your reading speed.
Create a free account to track your reading progress, build your reading list, and set reading goals.
Word Count
125,750 words, Guess
Page Count
503 pages
Identifiers
- Internet Archivehitleadprofiling00fall
- ISBN-103527323317
- ISBN-139783527323319
- Library of Congress Control Number2010286582
- OCLC Control Number525085003
and 2 more
- Better World Books9783527323319
- Open LibraryOL24495806M
Classifications
- LCCRS420 .H58 2009
- LCCRS420
Alternate Titles
- Identification and optimization of drug-like molecules
Description
(Publisher-supplied data) The only reference on current methods to generate pharmacokinetic and safety profiles of drug candidates, as well as how they must be balanced against one other for the best selection of candidates for further development. Following a brief introduction to the necessities of filtering and risk assessment of potential new drug molecules before actual drug development, the two equally important aspects of pharmacological (ADME) and safety (toxicity) profiling are covered in separate parts. The ADME section covers the profiling of basic physicochemical parameters, such as solubility and permeability, as well as more complex traits, such as the likelihood of drug-drug interactions, metabolic clearance and protein binding properties. The toxicology part addresses, among others, recent advances in early genetic toxicity testing, bioactivation screening, organ-specific toxicity assays for liver, heart, kidney and blood, as well as profiling for autoimmune reactions. By addressing both drug efficiency and drug safety, this modern practical reference shows readers how each individual aspect figures in shaping the key decisions on which the entire drug development process hinges. In short, this is a complete toolbox for assessing the risk/benefit ratio for any novel compound during the early drug development stages, using both in vitro and in silico methods. Both editors are based at one of the leading research-driven pharmaceutical companies, and the authors have been recruited from numerous other global players in the field. Invaluable know-how for every medicinal chemist and drug developer.
Subjects
Other Editions
- Hit and lead profiling: identification and optimization of drug-like molecules
Reader Reviews
No reviews yet for this book.
Be the first to share your thoughts!