Advancing Methods for Biomolecular Crystallography
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Author
Contributions
- Urzhumtsev, Alexandre G. - Contributor
- Lunin, Vladimir Y. - Contributor
- SpringerLink (Online service) - Contributor
Publication
2013 - Springer Netherlands, Dordrecht, Netherlands
Language
English
Word Count
90,500 words, Guess
Page Count
362 pages
Physical Format
[electronic resource] /
Identifiers
- Open LibraryOL27015389M
- ISBN-139789400762329
Classifications
- DDC543.2-543.8
- LCCQD95-96
Description
This work presents a snapshot of the state of the art of modern biomolecular crystallography, from crystallisation through structure determination and even interactive presentation on the web. Methods driving the latest automated structure determination pipelines are explained, as well as how to deal with problems such as crystal pathologies that still demand expert analysis. These methods are illustrated through their application to problems of great biological interest, such as the molecular machinery underlying the complement pathway, the mechanism of action of monoamine oxidase inhibitors, and the structure of the eukaryotic ribosome. Complementary approaches, such as neutron diffraction, small angle X-ray scattering, coherent diffraction and computational modelling, are also explored.
Subjects
Series Statement
- NATO Science for Peace and Security Series A: Chemistry and Biology
Other Editions
- Advancing Methods for Biomolecular Crystallography
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